Glutamate Dehydrogenase Applicability in Clinical Practice

Glutamate dehydrogenase (GLDH) catalyzes reversible deamination of glutamate into alpha-ketoglutarate and ammonium ion. In the metabolism a cell, GLDH has key role acting as an interface between carbohydrates amino acids in vicinity citric acid cycle urea cycle. brain, appears astrocytic processes associated with glutamatergic terminals, but it is also involved glia metabolic processes. probably protects postsynaptic membranes against neuroexcitotoxic effect. equally accurate marker alcoholism comparison to others, if its significantly faster decrease taken consideration. Watching changes activity laboratory markers alcoholism, after cessation drinking, effective yet overlooked aid diagnostics. The fast increase leukocytes specific for alcohol addiction. Alcohol consumption reduces some extent consecutively could lead increased protein production strengthen diminished leukocyte protective ability. gradual may be one factors neurodegenerative ageing cerebrospinal fluid patients disorders reasons probable nerve, nerve root plexus needs further investigations adequately understood.